Treatment of Advanced Heart Failure—Focus on Transplantation and Durable Mechanical Circulatory Support
نویسندگان
چکیده
Heart transplantation (HTx) is the treatment of choice in patients with late-stage advanced heart failure (Advanced HF). Survival rates 1, 5, and 10 years after are 87%, 77%, 57%, respectively, average life expectancy 9.16 years. However, because donor organ shortage, waiting times often exceed expectancy, resulting a list mortality around 20%. This review aims to provide an overview current standard, recent advances, future developments Advanced HF focus on long-term mechanical circulatory support HTx.
منابع مشابه
Mechanical circulatory support after paediatric heart transplantation.
OBJECTIVES Mechanical circulatory support (MCS) may be required after orthotopic heart transplantation (OHTx) in children for the treatment of failure or rejection. We review the incidence and outcomes of post-transplant MCS in our institution. METHODS MCS was classified as early (<1 month since transplant) or late (>1 month since transplant) and the support offered was either veno-arterial e...
متن کاملMechanical circulatory support for advanced heart failure.
OPINION STATEMENT Both acute and chronic systolic heart failure can progress to an advanced phase, resulting in stage D heart failure and even cardiogenic shock. Despite significant progress in the treatment of systolic heart failure using medical and device therapies, this terminal phase continues to be prevalent and associated with unacceptably high morbidity and mortality. Given the inabilit...
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Shortage of donors enhances harvesting of borderline hearts. When such organs fail, a ventricular assist device may salvage the patient waiting for either recovery or for retransplantation. We describe a series of 12 patients who required circulatory support following orthotopic heart transplantation, with the use of four different devices. Four patients survived. The aim of this study is to de...
متن کاملMechanical circulatory support and cardiac transplantation.
Congestive heart failure is not a specific disease but rather a clinical syndrome of diverse etiologies. This syndrome is characterized by ventricular dysfunction leading to decreased cardiac output; consequent neurohumoral activation leading to salt and water retention, with congestion in the pulmonary and systemic circulation; a “vicious circle” of blood-flow maldistribution; and eventual hyp...
متن کاملDurable Mechanical Circulatory Support versus Organ Transplantation: Past, Present, and Future
For more than 30 years, heart transplantation has been a successful therapy for patients with terminal heart failure. Mechanical circulatory support (MCS) was developed as a therapy for end-stage heart failure at a time when cardiac transplantation was not yet a useful treatment modality. With the more successful outcomes of cardiac transplantation in the 1980s, MCS was applied as a bridge to t...
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ژورنال
عنوان ژورنال: Heart Failure Clinics
سال: 2021
ISSN: ['2374-9334', '1551-7136']
DOI: https://doi.org/10.1016/j.hfc.2021.05.013